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慢性乙型肝炎患者体内乙肝病毒持续复制与免疫攻击造成肝细胞炎症破坏和肝组织纤维化,肝纤维化是慢性肝病向肝硬化发展的必经病理学过程,有效治疗肝纤维对于改善慢性肝病预后、降低病死率至关重要。有效抗肝炎病毒病因治疗下仍需重视抗肝纤维化治疗[1]。目前,核苷及核苷酸类药物是慢性乙型肝炎抗病毒治疗效果肯定的西药[2]。阿德福韦酯是新一代安全有效的核苷类抗病毒药物,其活性代谢产物阿德福韦二磷酸盐对乙型肝炎病毒基因(hepatitis B
Chronic hepatitis B patients with persistent hepatitis B virus replication and immune attack caused by damage to liver cells and liver fibrosis, liver fibrosis is the pathological process of development of chronic liver disease to liver cirrhosis, effective treatment of liver fibrosis to improve the prognosis of chronic liver disease , Reducing mortality is crucial. Effective anti-hepatitis virus etiology treatment still need attention to anti-liver fibrosis treatment [1]. At present, nucleosides and nucleotides are western medicines with definite therapeutic effect on chronic hepatitis B virus [2]. Adefovir dipivoxil is a new generation of safe and effective nucleoside antiviral drugs, the active metabolite of adefovir diphosphate hepatitis B virus gene (hepatitis B