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作者用口服黄连素治疗顽固性室上性阵发性心动过速2例,效果良好。男女各1例,病程2～5年,年龄分别为30及50岁。均曾用抗心律失常药物疗效不佳,改用黄连素0.2qid,无效增至0.3q6h。其中11例用药1周后症状消失。另1例经增加剂量4天后好转。黄连素治疗室上性阵速的作用机理尚未明确。有多位学者通过离体动物实验指出黄连素在离体标本上,小剂量可以兴奋心脏,而大剂量可以抑制心脏并有抗心律失常作用。同时有对抗肾上腺素的作用。
The author used oral berberine treatment of intractable paroxysmal supraventricular tachycardia in 2 cases, the effect is good. 1 case of male and female, duration of 2 to 5 years, aged 30 and 50 respectively. Have used anti-arrhythmic drugs ineffective, use berberine 0.2qid, invalid increased to 0.3q6h. Among them, 11 cases disappeared after 1 week of treatment. The other one improved after 4 days of dose increase. The mechanism of action of berberine in treating supraventricular tachycardia is not yet clear. Many scholars through ex vivo animal experiments that berberine in vitro specimens, a small dose can excite the heart, and large doses can inhibit the heart and anti-arrhythmic effect. At the same time there is a fight against adrenaline.