脊髓损伤患者常出现慢性便秘,其原因可能与结肠通过时间延长有关。普卡必利(Prucalopride)是一种高选择性、特异性的5-HT_4受体激动剂,有促进肠道动力的作用。本研究目的:评价普卡必利治疗脊髓损伤引起便秘的安全性、耐受性和效果。 方法:采用随机、双盲、安慰剂对照、小样本、准备剂量递增的方法进行研究。每个阶段前有4周的准备期评估患者的排便习惯并确认便秘的诊断。经过第一个准备期,患者被 Chronic constipation often occurs in patients with spinal cord injury, the reason may be related to prolonged colon passage. Prucalopride is a highly selective and specific 5-HT_4 receptor agonist with potent intestinal motility. The purpose of this study was to evaluate the safety, tolerability and efficacy of probucol on constipation caused by spinal cord injury. METHODS: Randomized, double-blind, placebo-controlled, small-sample, and dose escalation studies were performed. A 4-week preparation period prior to each stage evaluates the patient’s bowel habits and confirms the diagnosis of constipation. After the first readiness, the patient was