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目的:观察肝脾同治药物软肝颗粒对肝纤维化大鼠的抑制作用,并探寻其作用机制。方法:实验中将60只实验大鼠随机分为空白对照组、模型对照组、软肝颗粒组与活血化瘀4组。分别通过四氯化碳诱导成为肝纤维化模型大鼠,软肝颗粒组及活血化瘀组分别予软肝颗粒和大黄蛰虫丸灌胃,实验结束后检测各组大鼠行为学指标、肝脏病理组织学改变,以及HA、LN、PCⅢ、Ⅳ-C水平等指标,观察软肝冲剂对肝纤维化的治疗及逆转病程的作用。结果:软肝颗粒组及活血化瘀组HA、LN、PCⅢ及Ⅳ-C水平均低于模型对照组(P<0.01);软肝颗粒组HA、LN、PCⅢ及Ⅳ-C水平低于活血化瘀组(P<0.05)。结论:软肝颗粒对肝纤维化的抑制及逆转作用较活血化瘀法更具一定优势。
OBJECTIVE: To observe the inhibitory effect of Gangan Granule of liver and spleen Tongzhi on hepatic fibrosis in rats and explore its mechanism. Methods: Sixty experimental rats were randomly divided into blank control group, model control group, soft liver granules group and blood circulation of 4 groups. Respectively, induced by carbon tetrachloride to become liver fibrosis model rats, soft liver granules group and blood circulation group were given soft liver granules and rhubarb pestle pills intragastric administration, after the end of the experiment to detect the behavioral indicators of rats in each group, the liver Pathological changes, as well as HA, LN, PCⅢ, Ⅳ-C levels and other indicators to observe the soft capsule of liver fibrosis treatment and reverse the course of the role. Results: The levels of HA, LN, PCⅢ and Ⅳ-C in Ruanghu particles group and Huoxuehuayu group were lower than those in model control group (P <0.01). The levels of HA, LN, PCⅢ and Ⅳ- Huayu group (P <0.05). Conclusion: The Ruanghuang Granule can inhibit hepatic fibrosis and reverse the effect of blood circulation and blood circulation more certain advantages.