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目的探讨宫腔镜子宫内膜切除术对服用他莫昔芬的绝经后乳腺癌患者子宫内膜增生的抑制作用。方法选取服用他莫昔芬的绝经后乳腺癌患者35例,比较宫腔镜子宫内膜切除术(transcervical resection of endometrium,TCRE)前后子宫内膜的变化。结果宫腔镜子宫内膜切除术后,患者子宫腔修复层厚度较术前明显下降,在随访期间无子宫内膜息肉复发。结论在服用他莫昔芬的绝经后乳腺癌患者中,宫腔镜子宫内膜切除术能明显抑制他莫昔芬引起的子宫内膜增生反应,降低子宫内膜息肉的复发。
Objective To investigate the inhibitory effect of hysteroscopic endometrial ablation on endometrial hyperplasia in postmenopausal women with tamoxifen. Methods Thirty-five postmenopausal women with tamoxifen were enrolled in this study. The changes of endometrium before and after transcervical resection of endometrium (TCRE) were compared. Results After hysteroscopic endometrial resection, the thickness of the uterine cavity repair layer was significantly lower than that before the operation, and no recurrence of endometrial polyps was found during follow-up. Conclusion In patients with postmenopausal breast cancer taking tamoxifen, hysteroscopic endometrial ablation can significantly inhibit tamoxifen-induced endometrial hyperplasia and reduce the recurrence of endometrial polyps.