论文部分内容阅读
目的 探讨异丙嗪联用纳洛酮对火箭推进剂偏二甲基肼 (UDMH)中毒鼠的救治效果 ,以寻找防治的新途径。 方法 L ACA雄性小鼠 ,18～ 2 2 g,共 88只。按体重随机分成 4组 :对照组、异丙嗪组、纳洛酮组、异丙嗪 +纳洛酮联用组。模型制作 :经过预实验 ,取 UDMH给各组小鼠腹腔注射(15 .6 2 5 mg/ kg) ,制备腹腔中毒模型。治疗方法 :对照组给予腹腔注射生理盐水 0 .2 m l/只 ,纳洛酮组给予每只小鼠腹腔注射纳洛酮 0 .12 m g/ kg,异丙嗪组给予每只小鼠腹腔注射盐酸异丙嗪 7.5 mg/ kg,联用组同时给予腹腔注射纳洛酮 7.5 m g/ kg及盐酸异丙嗪 0 .12 m g/ kg。中毒后 15 min、1h分别腹腔内注射上述药物共 2次。注射完毕后观察小鼠的表现和存活情况。 结果 4组实验动物中 ,染毒后40 min纳洛酮组和联合组的存活率分别为 45 .4%和 5 9.1% ,高于对照组的 2 7.3% ;经过统计学分析 ,盐酸异丙嗪联用纳洛酮组的存活率与对照组的差异有显著性意义。 结论 盐酸异丙嗪联用纳洛酮可明显推迟 UDMH中毒小鼠痉挛的发生 ,提高小鼠的存活率
Objective To investigate the effect of promethazine combined with naloxone on the rodent propellant in rats exposed to dimethyl hydrazine (UDMH) in order to find a new way of prevention and treatment. Methods L ACA male mice, 18 ~ 2 2 g, a total of 88. Randomly divided into 4 groups according to body weight: control group, promethazine group, naloxone group, promethazine + naloxone combination group. Model Making: After preliminary experiments, UDMH was given intraperitoneally to each group of mice (15.625 mg / kg) to prepare model of intraperitoneal poisoning. Treatment: The control group was intraperitoneal injection of saline 0.2 ml / only, naloxone group were given intraperitoneal injection of naloxone 0.12 mg / kg, promethazine group given to each mouse intraperitoneal injection of hydrochloric acid Promethazine 7.5 mg / kg was given intraperitoneally in combination with naloxone 7.5 mg / kg and promethazine 0.12 mg / kg. 15 min after poisoning, 1h intraperitoneal injection of the above drugs were 2 times. After the injection, the performance and survival of the mice were observed. Results The survival rates of naloxone group and combination group at 40 min after exposure to the four experimental groups were 45.4% and 51.9%, respectively, which were higher than those of the control group (23.3%). After statistical analysis, There was a significant difference in survival between naloxone group and control group. Conclusion Promethazine hydrochloride combined with naloxone can significantly delay the occurrence of spasticity in mice with UDMH poisoning and improve the survival rate of mice