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目的:分析川芎嗪注射液不良反应的发生特点。方法:对1995年—2009年文献中报道的20例不良反应进行统计分析。结果:川芎嗪注射液的不良反应,男、女发生比率大致相同,以60岁以上老年人群发生率较高,其余各年龄段无明显差异。不良反应主要发生在用药lh以后,占不良反应的80%。主要涉及皮肤、呼吸系统、消化系统和心脑血管系统等损害。结论:临床应用川芎嗪注射液时应根据其不良反应的特点,密切观察患者的情况,并做好相应的防治预案。
Objective: To analyze the characteristics of the adverse reaction of ligustrazine injection. Methods: Statistical analysis of 20 adverse reactions reported in the literature from 1995 to 2009 was performed. Results: The adverse reaction of Ligustrazine injection was similar between males and females. The prevalence rates were higher in the elderly over 60 years old and no significant difference in other age groups. Adverse reactions mainly occur after treatment lh, accounting for 80% of adverse reactions. Mainly involves the skin, respiratory system, digestive system and cardiovascular system damage. Conclusion: The clinical application of ligustrazine injection should be based on the characteristics of its adverse reactions, the close observation of patients, and make the appropriate control plan.