甾类激素可通过与淋巴细胞的相互作用而影响免疫应答。性甾类激素可通过与细胞膜直接相互作用显示免疫抑制作用,其中孕酮(P)特别受到重视,以往研究证实它在体外主要抑制免疫应答的增殖和识别相,并有明显的“局部”免疫抑制作用。作者也曾发现一种分泌P的细胞,即小鼠滋养层细胞和卵巢细胞培养物及其上清液和P一样可抑制识别相和增殖相及细胞毒性T细胞在体外的发生。免疫识别和增殖过程中的一个重要表现是淋巴细胞能形成凝聚物,这种特性可通过提呈抗原、分泌淋巴因子、甚或二者而发生免疫信息的局部交换。因为 Steroid hormones can affect immune responses by interacting with lymphocytes. Steroid hormones show immunosuppressive effects by direct interaction with the cell membrane, of which progesterone (P) is of particular interest. Previous studies have demonstrated that it mainly inhibits the proliferation and identification of immune responses in vitro with a marked “local” immunization Inhibition. The authors also found that a P-secreting cell, a mouse trophoblast cell and an ovarian cell culture, and its supernatant, like P, inhibit the appearance and proliferation of cytotoxic T cells in vitro and in vitro. An important manifestation of immune recognition and proliferation is the ability of lymphocytes to form aggregates, a feature that allows local exchange of immune messages by presenting antigens, secreting lymphokines, or both. because