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目的:观察胰岛素联合格列美脲治疗2型糖尿病的疗效与安全性。方法:60例2型糖尿病患者随机分为单药组(胰岛素)和联合用药组(胰岛素+格列美脲),每组30人,疗程3个月,比较两组患者治疗前后血糖、糖化血红蛋白、胰岛素用量的变化,并记录低血糖反应次数。结果:2组患者治疗后血糖、糖化血红蛋白水平均显著降低;但联合用药组降低水平明显优于单药组。联合用药组胰岛素用量明显减少。两组低血糖反应次数无明显差异。结论:胰岛素联合格列美脲治疗2型糖尿病疗效好,并且安全。
Objective: To observe the efficacy and safety of insulin combined with glimepiride in the treatment of type 2 diabetes mellitus. Methods: Sixty patients with type 2 diabetes were randomly divided into single drug group (insulin) and combination group (insulin + glimepiride) with 30 patients in each group for 3 months. The levels of blood glucose, glycosylated hemoglobin , Changes in the amount of insulin, and record the number of hypoglycemic reactions. Results: The levels of blood glucose and glycosylated hemoglobin were significantly decreased in both groups after treatment, but the combination group was significantly better than the single drug group. The amount of insulin in combination group decreased obviously. No significant difference in the number of hypoglycemic reactions between the two groups. Conclusion: Insulin combined with glimepiride in the treatment of type 2 diabetes is effective and safe.