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目的:评价液基细胞学(TCT)联合高危型HPV(HR-HPV)对宫颈病变筛查的效力。方法:对112例宫颈病变筛查TCT阴性,HR-HPV阳性的患者,在电子阴道镜下取宫颈组织活检,以病理组织学诊断为金标准,评价HR-HPV在宫颈病变筛查中的意义。结果:在112例TCT阴性,HR-HPV阳性的患者中,病理学诊断为鳞状上皮内低度病变(LSIL)45例,占40.2%;鳞状上皮内高度病变(HSIL)14例,占12.5%。LSIL患者进行观察随访或破坏性治疗;HSIL患者给予宫颈电环切除性治疗。结论:作为宫颈病变的初筛方法,TCT存在一定的假阴性率,联合HR-HPV检测,能明显提高诊断的准确率,做到早期发现,早期治疗。
Objective: To evaluate the efficacy of liquid-based cytology (TCT) combined with high-risk HPV (HR-HPV) screening for cervical lesions. Methods: 112 cases of cervical lesions screening TCT-negative, HR-HPV-positive patients under electron colposcopy cervical biopsy, histopathological diagnosis as the gold standard, evaluation of HR-HPV in screening of cervical lesions significance . Results: Of the 112 TCT-negative and HR-HPV positive patients, pathological diagnosis was made in 45 cases (40.2%) of LSIL, 14 cases of squamous intraepithelial lesion (HSIL) 12.5%. LSIL patients were observed follow-up or destructive treatment; HSIL patients given cervical excision of the ring. Conclusion: As a screening method for cervical lesions, there is a certain false negative rate of TCT, combined with HR-HPV testing, can significantly improve the diagnostic accuracy, so early detection and early treatment.