许多物理或化学因子具有潜在的对基因组引起不利的遗传变化,导致基因型遗传上的不利改变,通常认为会导致突变的结果。然而,致突变作用并不是遗传改变的唯一机制,表观遗传基础对此也具有重要作用。DNA甲基化成为外遗传的基础机制已经倍受关注。基于甲基化异常与疾病之间的关系及近年毒物对DNA甲基化研究的基础,我们指出DNA甲基化改变在许多化学物毒性中起重要的作用,DNA甲基化状态评价对于全部安全性评价具有重要应用前景。 Many physical or chemical factors have the potential to cause adverse genetic changes in the genome, resulting in genetic adverse changes in genotypes, which are often thought to result in mutations. However, mutagenicity is not the only mechanism of genetic alteration, and epigenetic basis is also important. DNA methylation has become the basis of epigenetic mechanisms have received much attention. Based on the relationship between methylation abnormalities and diseases and the basis for the study of DNA methylation in recent years, we point out that DNA methylation plays an important role in many chemical toxicities. The assessment of DNA methylation status is of great importance to all safety Sexual evaluation has important application prospects.