论文部分内容阅读
目的:了解HPV L1壳蛋白联合HPV、Survivin检测在诊断宫颈癌前病变中的作用。方法:回顾性地对该医院妇科门诊2007年7月～2011年5月进行HPV L1壳蛋白联合HPV、Survivin检测的284例患者进行总结和分析。结果:HPV L1壳蛋白随着宫颈病变程度的加重呈现下降趋势,其在CINⅠ组和CINⅡ组中的阳性率显著高于对照组(P<0.05)。HPV病毒随着宫颈病变程度的加重呈现上升趋势,其在CINⅠ组、CINⅡ组、CINⅢ组和SCC组中的阳性率显著高于对照组(P<0.05)。Survivin随着宫颈病变程度的加重呈现上升趋势,其在CINⅢ组和SCC组中的阳性率显著高于对照组(P<0.05)。HPV L1壳蛋白和HPV病毒表达呈负相关,HPV病毒与Survivin表达呈正相关(P<0.05)。结论:HPV L1壳蛋白联合HPV、Survivin检测可以作为预测宫颈癌前病变进展的生物学标志物。
Objective: To investigate the role of HPV L1 capsid protein in combination with HPV and Survivin in the diagnosis of cervical precancerous lesions. Methods: 284 patients with HPV L1 capsid protein and Survivin were retrospectively reviewed and analyzed in the gynecology clinic of our hospital from July 2007 to May 2011. Results: The HPV L1 capsid protein showed a decreasing trend with the severity of cervical lesions. The positive rate of HPV L1 in CINⅠ and CINⅡ groups was significantly higher than that in the control group (P <0.05). The HPV virus showed an increasing trend with the severity of cervical lesions. The positive rate of HPV in CINⅠgroup, CINⅡgroup, CINⅢgroup and SCC group was significantly higher than that of the control group (P <0.05). The positive rate of Survivin increased with the severity of cervical lesions. The positive rate of Survivin in CIN Ⅲ group and SCC group was significantly higher than that in control group (P <0.05). The HPV L1 capsid protein was negatively correlated with the expression of HPV virus, and the HPV virus was positively correlated with the expression of Survivin protein (P <0.05). Conclusion: HPV L1 capsid protein combined with HPV and Survivin can be used as biomarkers to predict the progression of cervical precancerous lesions.