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四川盐源县青石棉进行大鼠胸膜腔染尘后分别于12,15,18个月测定了血浆过氧化脂质(LPO)和超氧化物歧化酶(SOD)含量。LPO值随染尘时间延长逐渐上升,分别为3.078,3.918和5.565μg/ml血浆,与对照组比较差异有显著性(P<0.05)。SOD含量变化不显著,从而提出SOD/LPO比值评价体内氧化和抗氧化能力的关系。实验组较对照组比值下降明显,提示大鼠接触青石棉后脂质过氧化作用加强,机体抗氧化能力减弱,这可能是石棉致病的原因。
The contents of lipid peroxidation lipid (LPO) and superoxide dismutase (SOD) were determined at 12, 15, and 18 months after crocidosis in Yanbian County, Sichuan Province. The value of LPO increased gradually with the prolongation of dusting time, which were respectively 3.078, 3.918 and 5.565μg / ml plasma, which was significantly different from the control group (P <0.05). SOD content was not significantly changed, thus proposed SOD / LPO ratio evaluation of the relationship between oxidation and antioxidant capacity. Compared with the control group, the ratio of the experimental group decreased significantly, suggesting that the lipid peroxidation of the rats exposed to crocidolite strengthened, the body antioxidant capacity weakened, which may be the cause of asbestos pathogenesis.