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目的了解新疆伊犁州人类免疫缺陷病毒(HIV)感染者早期高效抗逆转录病毒治疗后效果及相关影响因素。方法收集淋巴细胞计数>350个/μl研究对象的基线情况及治疗后各随访时点相关资料并进行统计分析。结果共收集651例HIV感染者信息,基线CD_4~+T淋巴细胞计数为(489.0±138.0)个/μl;治疗后3、6、9、12、18、24、30个月CD_4~+T淋巴细胞计数与基线相比分别上升了59.8、89.0、104.9、100.9、109.9、112.7和120.9个/μl,差异有统计学意义(P<0.05);免疫应答成功率为58.0%,临床分期为Ⅰ或Ⅱ期(OR=0.359,95%CI:0.138~0.934)、未合并丙型肝炎(OR=0.530,95%CI:0.304~0.925)、基线CD_4~+T淋巴细胞计数350~500个/μl(OR=0.559,95%CI:0.387~0.826)、未因依从性差曾停止治疗(OR=0.531,95%CI:0.319~0.883)的研究对象病毒抑制率要高于相应的对照组,差异有统计学意义(P<0.05);病毒抑制率为78.8%,分析发现各组间差异无统计学意义(P>0.05)。结论新疆伊犁州HIV感染者在早期启动抗病毒治疗后取得了较好的效果。
Objective To understand the effect of early anti-retroviral therapy in HIV-infected patients in Ili prefecture, Xinjiang and related factors. Methods The baseline data of lymphocyte count> 350 / μl and the related data at each follow-up after treatment were collected and statistically analyzed. Results A total of 651 HIV-infected patients were collected. The baseline CD_4 ~ + T lymphocyte counts were (489.0 ± 138.0) / μl. CD_4 ~ + T lymphocytes at 3,6,9,12,18,24 and 30 months after treatment The cell count increased by 59.8, 89.0, 104.9, 100.9, 109.9, 112.7 and 120.9 / μl respectively compared with the baseline, the difference was statistically significant (P <0.05); the success rate of immune response was 58.0% (OR = 0.359, 95% CI: 0.138-0.934), without hepatitis C (OR = 0.530, 95% CI: 0.304-0.925). The baseline CD_4 ~ + T lymphocyte counts were 350-500 / OR = 0.559, 95% CI: 0.387-0.826), and the rate of virus suppression in those who did not stop treatment due to poor compliance (OR = 0.531,95% CI: 0.319-0.883) was higher than that of the corresponding control group (P <0.05). The virus inhibition rate was 78.8%. There was no significant difference among the groups (P> 0.05). Conclusion The HIV infection in Yili Prefecture of Xinjiang Autonomous Region has achieved good results after early initiation of antiviral therapy.