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自身免疫性溶血性贫血(AIHA)的自身抗体具有血型抗原特异性。本组50例AIHA患者自身抗体经血型抗原特异性鉴定(乙醚冼脱法),发现7例具有相对特异性,其中抗D1例,抗E2例,抗e4例。自身抗体血型抗原特异性鉴定是AIHA患者合理选择供血的指导。若给AIHA患者输入携有与其自身抗体相对应的抗原的红细胞,则溶血更为严重。本资料7例相对特异性患者中有1例接受输血,其自身抗体为抗Rho(D),输入Rho(D)血,结果病情反而加重。本实验根据免疫学原理,从亚细胞水平显示了AIHA自身抗体在红细胞膜上的作用部位。
Autoantibodies to autoimmune hemolytic anemia (AIHA) are blood group antigen specific. The 50 cases of AIHA patients with autoantibodies specific identification of blood group antigen (ether Xianfu method), found in 7 patients with relative specificity, including anti-D1 cases, anti-E2 cases, anti-e4 cases. Autoantibodies Specific identification of blood group antigens is a guideline for rational choice of blood supply in AIHA patients. Hemolysis is more severe if red blood cells carrying antigens corresponding to their autoantibodies are input to AIHA patients. This data in 7 cases of relative specificity of patients receiving transfusion, the autoantibodies against Rho (D), the input of Rho (D) blood, the results actually aggravated. According to the immunological principle, this experiment shows the role of AIHA autoantibodies on the erythrocyte membrane from the subcellular level.