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目的比较国产利培酮与合资利培酮在治疗精神分裂症时的疗效和副作用。方法分组临床对照治疗,采用阳性与阴性症状量表(PANSS)进行疗效评估以及不良反应症状量表(TESS)进行安全评估。结果两组PANSS评分都较治疗前显著降低(两者P<0.05),国产利培酮有效率为70%,合资利培酮有效率为63.3%,无显著性差异;TESS比较差异无显著性(P>0.05)。结论国产利培酮与合资利培酮在治疗精神分裂症所表现之效果相当,都比较有效且安全性良好。
Objective To compare the efficacy and side effects of domestic risperidone and risperidone in the treatment of schizophrenia. Methods The clinical control group was divided into two groups. The positive and negative symptom scales (PANSS) were used to evaluate the curative effect and the adverse reaction symptom scale (TESS) for safety evaluation. Results The PANSS scores of both groups were significantly lower than those before treatment (both P <0.05). The effective rate of domestic risperidone was 70% and the effective rate of joint risperidone was 63.3%, there was no significant difference. There was no significant difference in TESS (P> 0.05). Conclusion Domestic Risperidone and Risperidone in the treatment of schizophrenia showed the same effect, are more effective and safe.