迟相林(潍坊医学院附属文登中心医院神经内科,山东威海264400)从遗传学角度来看,高尿酸血症(hyperuricemia,HUA)的形成并非单基因疾病,而是与很多微效基因的加和作用有关。相同的尿酸水平,可能具有不同的基因遗传背景。此时,需要考虑何种基因是主要的易感性基因。另外,基因是否发挥作用和基因作用的最终结果(表型)是什么,还受到环境因素的影响,这时需要考虑基因本身和环境因素的相互作用。也就是说,影响尿酸代谢、糖代谢、脂代谢及血压调节的很多基因都具有关联性,而何种基因为主将导致不同的临床风 Chi Xianglin (Department of Neurology, Wendeng Hospital Affiliated to Weifang Medical College, Weihai 264400, China) From a genetic point of view, the formation of hyperuricemia (HUA) is not a single gene disease, And the role. The same uric acid level may have a different genetic background. At this point, you need to consider which genes are the major susceptibility genes. In addition, the role of genes and the ultimate result of the role of genes (phenotype) is also affected by environmental factors, then need to consider the interaction between genes and environmental factors. In other words, many genes that affect uric acid metabolism, glucose metabolism, lipid metabolism and blood pressure regulation are related, and what kind of genes are predominant will lead to different clinical epidemics