With the rapid development of the genomic sequencing technology,the cost of obtaining personal genomic data and effectively analyzing it has been gradually reduced.The analysis and utilization of genomic data gradually entered the public view,and the leakage of genomic data privacy has attracted the attention of researchers.The security of genomic data is not only related to the protection of personal privacy,but also related to the biological information security of the country.However,there is still no effective genomic data privacy protection scheme using Shangyong Mima(SM) algorithms.In this paper,we analyze the widely used genomic data file formats and design a large genomic data files encryption scheme based on the SM algorithms.Firstly,we design a key agreement protocol based on the SM2 asymmetric cryptography and use the SM3 hash function to guarantee the correctness of the key.Secondly,we used the SM4 symmetric cryptography to encrypt the genomic data by optimizing the packet processing of files,and improve the usability by assisting the computing platform with key management.Software implementation demonstrates that the scheme can be applied to securely transmit the genomic data in the network environment and provide an encryption method based on SM algorithms for pro-tecting the privacy of genomic data.