Uric formaldehyde levels are negatively correlated with cognitive abilities in healthy older adults

来源 :Neuroscience Bulletin | 被引量 : 0次 | 上传用户:beemoon
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Recent studies have shown that the abnormal accumulation of endogenous formaldehyde could be a critical factor in age-related cognitive decline. The aim of this study was to estimate the correlation between uric formaldehyde and general cognitive abilities in a community-based elderly population, and to measure the extent and direction in which the correlation varied with demographic characteristics. Using a double-blind design, formaldehyde in human urine was analyzed by high-performance liquid chromatography(n = 604), and general cognitive abilities were measured using the Montreal Cognitive Assessment(MoCA). Demographic characteristics, in terms of age, gender, residential region, and education were taken into consideration. We found that uric formaldehyde levels were inversely correlated with the MoCA score, and the concentration varied with demographic features: higher odds of a high formaldehyde level occurred among the less educated and those living in old urban or rural areas. In cytological experiments, the level of cellular formaldehyde released into the medium increased as SH-SY5Y and BV2 cells were incubated for three days. Formaldehyde in excess impairedthe processes of N2a cells and neurites of primary cultured rat hippocampal cells. However, removal of formaldehyde markedly rescued and regenerated the processes of N2a cells. These results demonstrated a negative correlation between the endogenous formaldehyde and general cognitive abilities. High formaldehyde levels could be a risk factor for cognitive impairment in older adults, and could be developed as a non-invasive marker for detection and monitoring of age-related cognitive impairment. Recent studies have shown that the abnormal accumulation of endogenous formaldehyde could be a critical factor in age-related cognitive decline. The aim of this study was to estimate the correlation between uric formaldehyde and general cognitive abilities in a community-based elderly population, and to measure the extent and direction in which the correlation varied with demographic characteristics. Using a double-blind design, formaldehyde in human urine was analyzed by high-performance liquid chromatography (n = 604), and general cognitive abilities were measured using the Montreal Cognitive Assessment We found that uric formaldehyde levels were inversely correlated with the MoCA score, and the concentration varied with demographic features: higher odds of a high formaldehyde level occurred among the less educated and those living in old urban or rural areas. In cytological experiments, the level of cellular formaldehyde released into the medium increased as SH-SY5Y and BV2 cells were incubated for three days. Formaldehyde in excess impaired the processes of N2a cells and neurites of primary cultured rat hippocampal cells. However, removal of formaldehyde markedly rescued and regenerated the processes of N2a cells. These results demonstrated a negative correlation between the endogenous formaldehyde and general cognitive abilities. High formaldehyde levels could be a risk factor for cognitive impairment in older adults, and could be developed as a non-invasive marker for detection and monitoring of age-related cognitive impairment.
其他文献
摘 要:结合海南东线高速公路采用就地热再生技术,在旧路面改造应用的工程实例,分析总结复拌形就地热再生技术的配合比设计、路面复拌形再生技术的施工要点。  关键词:旧路面 就地热再生 复拌形  中图分类号:U416 文献标识码:A 文章编号:1007-3973(2013)012-012-02  1 绪论  公路沥青路面,具有表面平整、无接缝、行车舒适、噪音小、耐磨、养护维修简便等优点,公路路面现以铺设
近年来学术期刊出版领域出现了代发论文现象并形成了产业链。课题组从调查研究论文代发现象中被代理学术期刊、论文及其作者、代发论文中介三个环节切入,探寻论文代发的成因
目的探讨低出生体重儿(LBWI)的原因和防治措施。方法对545例LBWI(出生时体重低于2500克)的发生和死因进行回顾性分析。结果LBWI母亲妊娠期并发症,如流感、中重度贫血和妊娠高血压综合征等明显增高。LBWI死
交换齿轮亦称变换齿轮、配换齿轮、挂轮。其选择方法一般有查表法和计算法。查表法是一种简单、可靠的方法,但是手头必须要有表。当所查的挂轮比表中没有时,则需要进行计算
北方某地隧道二次衬砌需要在冬季进行浇注施工,由于气温低、现成施工案例少,困难较大,本文基于寒冷条件下隧道二次衬砌的冬季施工展开阐述,对混凝土的浇注方法、所采取的保暖
喀斯特地表水和地下水的交换活跃,地下水系统容易受到地表污染物的污染。为了解喀斯特城市地表水—地下水系统污染特征和污染物质来源,对贵阳市地表水、地下水、雨水和城市排
拖拉机水箱开锅后,发动机温度过高,零部件膨胀会使各部件配合间隙减小,同时温度过高使机油黏度降低,导致发动机各部件磨损加剧。若不立即做适当处理,发动机很可能烧损导致严
有人曾说郭为“40%是自己,60%继承了柳传志”。郭为也承认在说话、做事很多方面可能是无意识地在模仿柳传志,但他最主要的还是希望能够吸收柳总的思想上的东西。“当然,从我个人来讲,做
Objective:To identify the vectors and reservoirs of cutaneous leishmaniasis in the endemic focus of Farashband,Fars Province,South of Iran.Methods:Sticky papers
标题化合物是FeCl3·6H2O和TPA·3HClO4(TPA= (C6H6N)3N) 在甲醇溶液中反应得到的橙色晶体。X-射线衍射测定了其单晶结构。结果表明,该晶体属单斜晶系, C2/c 空间群。化学式:C36 H36 Cl4Fe2N8O9, Mr = 978.22, a= 16.300(3), b=17.180 (3), c= 16.582(3) , β= 111.75(3)°, V= 4131 3, Z= 4, Dc= 1.299g/cm 3, μ(MoKα) = 8.43 cm - 1, 42