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目的:探讨急性冠状动脉综合征(ACS)与血清总胆红素(TBil)、尿酸(UA)及纤维蛋白原(FIB)含量的相关性。方法:采集空腹静脉血检测124例在本院心血管内科患者和74例健康体检者的血总胆红素、尿酸、纤维蛋白原、血脂水平含量。将ACS患者分为不稳定型心绞痛组和急性心肌梗死组,与对照组比较血清总胆红素、尿酸、纤维蛋白原、血脂水平含量的差异,并进行血清总胆红素与血脂Pearson直线相关,并分析其通过冠状动脉造影后95例冠状动脉病变程度的相关性。结果:不稳定型心绞痛组和急性心肌梗死组的血清总胆红素水平均明显低于对照组;尿酸、纤维蛋白原含量明显高于对照组,差异均有统计学意义(P<0.01)。不稳定型心绞痛组和急性心肌梗死组之间血清总胆红素、尿酸、纤维蛋白原水平差异无统计学意义(P>0.05)。血清总胆红素与总胆固醇、甘油三酯、低密度脂蛋白均呈负相关(P<0.05);与高密度脂蛋白呈正相关(P<0.05)。尿酸和纤维蛋白原均随冠状动脉病变程度的加重而增高,与之呈正相关(p<0.01);血清总胆红素水平随冠状动脉病变程度的加重而降低,与之呈负相关(P<0.01)。结论:尿酸和纤维蛋白原含量的升高及血清总胆红素含量的降低与ACS的发生和冠状动脉病变严重程度密切相关,高尿酸和纤维蛋白原及低血清总胆红素是冠状动脉病变严重的独立危险因素,对ACS发生的预测、诊断和防治有一定意义。
Objective: To investigate the correlation between acute coronary syndrome (ACS) and serum total bilirubin (TBil), uric acid (UA) and fibrinogen (FIB). Methods: Fasting venous blood was collected to detect the levels of total bilirubin, uric acid, fibrinogen and blood lipids in 124 cardiovascular patients and 74 healthy subjects in our hospital. ACS patients were divided into unstable angina pectoris group and acute myocardial infarction group, compared with the control group, serum total bilirubin, uric acid, fibrinogen, blood lipid level differences, and serum total bilirubin and blood lipid Pearson linear correlation , And analyzed the correlation of 95 cases of coronary artery lesions after coronary angiography. Results: The levels of serum total bilirubin in unstable angina pectoris group and acute myocardial infarction group were significantly lower than those in control group. The contents of uric acid and fibrinogen were significantly higher than those in control group (P <0.01). There was no significant difference in serum total bilirubin, uric acid and fibrinogen between unstable angina pectoris group and acute myocardial infarction group (P> 0.05). Serum total bilirubin was negatively correlated with total cholesterol, triglyceride and low density lipoprotein (P <0.05), but positively correlated with high density lipoprotein (P <0.05). Uric acid and fibrinogen both increased with the severity of coronary artery disease (P <0.01), while serum total bilirubin level decreased with the severity of coronary artery disease (P < 0.01). Conclusion: The increase of uric acid and fibrinogen and the decrease of serum total bilirubin content are closely related to the occurrence of ACS and the severity of coronary artery disease. Hyperuricemia and fibrinogen and low serum total bilirubin are coronary artery disease Serious independent risk factors for the occurrence of ACS prediction, diagnosis and prevention have some significance.