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目的 临床观察自体外周血干细胞移植 (APBSCT)后 ,应用免疫抑制剂环孢菌素A(CsA)诱导 ,γ 干扰素 (γ IFN)增强自体移植物抗宿主病 (GVHD)的抗肿瘤效应。方法 急性白血病(AL) 4例 ,淋巴瘤 (ML) 4例 ,乳腺癌术后 2例均行APBSCT ,治疗组 (5例 )加用CsA、γ IFN ,对照组 (5例 )仅行APBSCT ,对照外周血白细胞、中性粒细胞、血小板回升时间 ,GVHD出现情况 ,随访持续缓解 (CCR)及复发情况。结果 治疗组外周血像回升较对照组略缓 ;治疗组 4例出现皮损为主的GVHD ,对照组未出现。CCR时间治疗组 2 0 (4～ 30 )个月较对照组 10 (2～ 2 0 )个月延长 ,复发率治疗组 2 0 % (1/ 5 ) ,较对照组 6 0 % (3/ 5 )明显降低。结论 APBSCT后加用CsA及γ IFN若出现自体GVHD ,则抗肿瘤效应明显。
Objective To observe the anti-tumor effect of autoantibodies against cyclosporine A (CsA) and gamma interferon (IFN-γ) after autologous peripheral blood stem cell transplantation (APBSCT) in patients with autoimmune graft-versus-host disease (GVHD). Methods Four cases of acute leukemia (AL), four cases of lymphoma (ML) and two cases of postoperative breast cancer were treated with APBSCT. The treatment group (5 cases) plus CsA and γ IFN and the control group (5 cases) Control leukocytes, neutrophils, platelet rise time, the occurrence of GVHD, follow-up sustained relief (CCR) and relapse. Results The recovery of peripheral blood in the treatment group was slightly slower than that in the control group. In the treatment group, GVHD mainly occurred in 4 cases, but not in the control group. The recurrence rate was 20% (1/5) in the CCR treatment group compared with 10 (2- 20) months in the control group (20%) compared with the control group (60%) )Obvious reduction. Conclusions After anti-tumor effect of APBSCT with CsA and γ IFN if there is autologous GVHD,