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20月龄的老龄大鼠血浆性激素含量减少(p<0.01),促性腺激素含量增加。二仙汤及其温肾益精养血和滋阴泻相火两个拆方均能分别提高老龄雄性大鼠血浆睾酮(p<0.05)和老龄雌性大鼠血浆雌二醇(p<0.01、p<0.05)的含量,降低两者血浆黄体生成激素的含量。认为二仙汤及其拆方对更年期综合征的疗效可能与提高血浆性激素水平有关。本文还就二仙汤及其两个拆方的作用差异进行了探讨。
The 20-month-old aged rats had reduced levels of plasma sex hormones (p<0.01) and increased gonadotropin levels. The two prescriptions of Erxian Decoction, Wenshen Yijing Nourishing and Ziyin Xiexiang Huo can both increase plasma testosterone (p<0.05) and plasma estradiol in aged female rats (p<0.01, respectively). The content of p<0.05) decreased the plasma luteinizing hormone content. It is believed that the efficacy of Erxian Decoction and its disassembled prescriptions on menopausal syndrome may be related to the increase of plasma sex hormone levels. This article also discusses the differences in the effects of Erxian Tang and its two separate prescriptions.