论文部分内容阅读
维生素D不仅可调节钙磷代谢，而且可抑制增殖、调节部分激素的分泌和肌肉力量等，与多种危重病的发生、发展密切相关。维生素D缺乏在人群中普遍存在，危重症患者中尤为常见，且与患者的高病死率、重症监护室停留时间、高脓毒症的发生率以及需长时间机械通气等相关。补充维生素D对于正常人群和重症患者是相对安全的，很少有不良反应的报道。治疗性维生素D补充可改善患者预后，但给药剂量、给药次数和确切的临床改善还未完全阐明。“,”In recent years,more and more studies show that the function of vitamin D is not only limited to regulating the calcium and phosphorous metabolism,but also involves anti-proliferation,regulation of hor-mone section,and muscle strength,thus is associated with the onset and development of many critical disea-ses.Vitamin D deficiency is very common in the population ,especially in critical patients,which is associated with the high mortality,high sepsis incidence,long duration of mechanical ventilation,and length of ICU stay.Vitamin D supplementation has been observed to be relatively safe in both healthy and critically ill patients with minimal reports of adverse effect .Vitamin D supplementation may prevent poor clinical out-comes,however,the dosing,frequency,and actual clinical improvements are yet to be elucidated .