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目的了解平顶山矿务局妇女宫颈病变及人乳头瘤病毒感染的发生率,为防治工作提供依据。方法 2011年平顶山矿务局妇女病普查共8338例,对其进行宫颈细胞薄层液基细胞学检查,细胞学检查结果为未明确诊断意义的不典型鳞状上皮细胞及以上病变的共计204例,对其均进行HPV导流杂交技术检测,发现上皮内瘤变的患者86例均行阴道镜检查并活检,病理确诊。结果低危型HPV感染47例,高危型HPV感染为82例,75例未查见HPV感染。宫颈上皮内瘤变及以上病变的86例,其中宫颈上皮内瘤变Ⅰ级47例(40例为低危型HPV感染,高危型HPV感染率4例,3例未见HPV感染),宫颈上皮内瘤变Ⅱ级18例,均为高危型HPV感染,宫颈上皮内瘤变Ⅲ级11例,均为高危型HPV感染,宫颈原位癌6例,均为高危型HPV感染,早期浸润癌为4例,均为高危型HPV感染。结论高危型人乳头状瘤病毒感染是宫颈病变及宫颈癌的主要原因。
Objective To understand the incidence of cervical lesions and human papillomavirus (HPV) infection among women in Pingdingshan Mining Bureau and provide basis for prevention and treatment. Methods 2011 Pingdingshan Bureau of Mines womens disease survey of a total of 8338 cases of cervical smear-based liquid-based cytology, cytological examination results for not clear diagnosis of atypical squamous cell and the above lesions a total of 204 cases, All of them were HPV-mediated hybridization detection technology and found that 86 cases of intraepithelial neoplasia colposcopy and biopsy, pathological diagnosis. Results 47 cases of low-risk HPV infection, high-risk HPV infection in 82 cases, 75 cases did not detect HPV infection. Cervical intraepithelial neoplasia and the above lesions of 86 cases, including cervical intraepithelial neoplasia grade Ⅰ 47 cases (40 cases of low-risk HPV infection, high-risk HPV infection in 4 cases, 3 cases of HPV infection), cervical epithelium 18 cases of internal tumor grade Ⅱ, were high-risk HPV infection, cervical intraepithelial neoplasia grade 11 cases were high-risk HPV infection, cervical carcinoma in situ in 6 cases, are high-risk HPV infection, early invasive carcinoma is 4 cases were high-risk HPV infection. Conclusion High-risk human papilloma virus infection is the main cause of cervical lesions and cervical cancer.