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目的:探讨米非司酮配合桂枝茯苓丸治疗子宫肌瘤的临床疗效。方法:将诊断为子宫肌瘤的患者,随机分成对照组与研究组,每组各40例。对照组采取口服米非司酮治疗,研究组采取桂枝茯苓丸联合米非司酮治疗,所有患者均不间断口服药物3个月,并且排除其他药物干扰。治疗前后,检测两组血清促卵泡素、黄体生成素、雌二醇及孕激素水平。结果:2组患者持续用药3个月之后,2组患者经量、经期、痛经以及腰部酸胀等症状较治疗前得到显著改善,其中研究组效果更为显著,血清FSH、LH、E2、P的浓度较对照组均明显降低(P<0.05),随访3个月年发现两组患者病情恢复情况良好,复发率小。结论米非司酮与桂枝茯苓联合治疗子宫肌瘤疗效明显优于单独使用米非司酮,值得临床进一步研究推广应用。
Objective: To investigate the clinical efficacy of mifepristone combined with Guizhi Fuling pill in the treatment of uterine fibroids. Methods: The diagnosis of uterine fibroids patients were randomly divided into control group and study group, 40 cases in each group. The control group was treated with oral mifepristone. The study group was treated with Guizhi Fuling pill combined with mifepristone. All patients received oral medication for 3 months without interruption and other drugs were excluded. Before and after treatment, two groups of serum testosterone, luteinizing hormone, estradiol and progesterone levels were measured. Results: After 3 months of continuous medication, the symptoms of menstruation, menstrual cramps and waist soreness in the two groups were significantly improved after treatment, in which the effect of the study group was more significant, the serum FSH, LH, E2, P (P <0.05). After 3 months of follow-up, the patients in both groups showed good recovery and a small recurrence rate. Conclusion The combination of mifepristone and Guizhi Fuling decoction for the treatment of uterine fibroids is obviously superior to that of mifepristone alone, which deserves further clinical application.