氟哌酸(norfloxacin)为氟喹诺酮类衍生物、具有强大的抗菌活性。本文选用3种临床分离的大肠杆菌、绿脓杆菌和金黄色葡萄球菌,用试管法先分别测出氟哌酸、青毒素、氨苄青霉素、头孢哌酮、硫酸丁胺卡那霉素、利福平、氯林可霉素、氯霉素对其最低抑菌浓度(MIC),然后采用二倍系列稀释法两药交叉组合,观察氟哌酸与其它7种抗生系体外相互作用。实验方法联合敏感实验分为协同、相加、无关、拮抗。协同: Norfloxacin is a fluoroquinolone derivative with strong antibacterial activity. In this paper, three kinds of clinical isolates of E.coli, Pseudomonas aeruginosa and Staphylococcus aureus were selected, and first of all, norfloxacin, penicillin, ampicillin, cefoperazone, amikacin, , Clindamycin, and chloramphenicol (MIC). Then the two-fold serial dilution method was used to study the interaction between norfloxacin and other 7 kinds of antibiotics. Experimental methods combined with sensitive experiments divided into synergy, add, irrelevant, antagonistic. Synergy: