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目的:研究龙蚁清风抗风湿浓缩颗粒结合小剂量甲氨喋呤治疗类风湿性关节炎(Rheumatoid arthritis RA)的临床疗效优势。方法:中药组用龙蚁清风抗风湿浓缩颗粒30例,西药组用甲氨喋呤(methotrexate MTX)30例,中西医结合组用龙蚁清风抗风湿浓缩颗粒结合小剂量甲氨喋呤30例,观察三组在治疗开始,3月、6月、12月、15月、18月、21月、24月关节疼痛数、肿胀数、病情活动度DAS(disease activity score)变化,检测血常规、血沉(ESR)、C反应蛋白(CRP)、类风湿因子(RF)、免疫球蛋白(IgM),每个月检查1次肝肾功能。结果:①研究结果证明中药组和中西医结合组均能显著改善RA患者ESR、CRP、IgM、DAS值,在提升RA患者血红蛋白含量、红细胞计数,降低血小板计数方面,两组均明显优于MTX。②中西医结合组总有效率与中药组比较,P均<0.05,差异有显著性。结论:龙蚁清风抗风湿浓缩颗粒结合小剂量甲氨喋呤治疗RA具有明显的治疗优势,能够起到增效减毒的治疗作用,很值得临床推广应用。
Objective: To study the clinical efficacy of Longfeng breeze anti-rheumatoid granules combined with low-dose methotrexate in the treatment of rheumatoid arthritis (RA). Methods: The traditional Chinese medicine group was treated with Longfeng breeze anti-rheumatoid concentrated granules in 30 cases, Western medicine group with methotrexate (methotrexate MTX) in 30 cases. The Integrative Medicine group was treated with Longfeng Qingfeng anti-rheumatic granules and 30 cases of low-dose methotrexate The changes of DAS (disease activity score), joint pain, swelling, disease activity score in the three groups were observed at the beginning of treatment, March, June, December, 15, 18, Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), immunoglobulin (IgM), check liver and kidney function once a month. Results: ①The results showed that both traditional Chinese medicine and western medicine combination group could significantly improve the ESR, CRP, IgM and DAS in patients with RA, and the two groups were significantly better than MTX in improving the hemoglobin content, erythrocyte count and platelet count in RA patients . ② The total effective rate of traditional Chinese medicine combined with traditional Chinese medicine group, P <0.05, the difference was significant. Conclusion: The treatment of RA with anti-rheumatoid granules and long-term low dose methotrexate has significant therapeutic advantages and can play a synergistic and attenuating therapeutic effect. It is worthy of clinical application.