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报道用长春新碱与强的松联合治疗小儿肾病综合征30例(单纯性20例,肾炎性10例)。9例作肾活检,病理诊断:系膜增殖性肾炎5例,膜增殂性肾炎2例,膜性肾病和微小病变肾病各1例。18例因肾病复发来治。治疗结果:27例(90%)得完全缓解,其中包括2例膜增殖性肾炎、1例膜性肾病、1例微小病变肾病和4例系膜增殖性肾炎。经平均4年的随访,6例(22.2%)复发。在长春新碱用药过程中未见明显副作用。由于缓解率高、复发率低、副作用轻、无性腺抑制之虞,联合疗法为小儿肾病综合征提供了一种安全有效的治疗措施。
Reported with vincristine and prednisone in the treatment of children with nephrotic syndrome in 30 cases (simple 20 cases, 10 cases of nephritis). 9 cases of renal biopsy, pathological diagnosis: 5 cases of mesangial proliferative glomerulonephritis, membranous nephritis in 2 cases, membranous nephropathy and minimal nephropathy in 1 case. 18 cases of relapse due to kidney disease to rule. Treatment outcome: Twenty-seven patients (90%) were completely relieved, including 2 cases of membranoproliferative glomerulonephritis, 1 case of membranous nephropathy, 1 case of minimal change nephropathy and 4 cases of mesangial proliferative glomerulonephritis. After an average of 4 years of follow-up, 6 patients (22.2%) relapsed. Vincristine medication in the course of no significant side effects. Because of high remission rate, low recurrence rate, light side effects, no gonadal suppression, combination therapy provides a safe and effective treatment for pediatric nephrotic syndrome.