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目的观察乳清蛋白粉对非酒精性脂肪肝(NAFLD)的干预效果。方法选择确诊NAFLD并进行生活方式干预的患者61例作为研究对象,其中女12例,男49例。随机分为对照组20例,实验组41例,进行12周治疗观察。为对照组患者提供符合NAFLD营养治疗原则的食谱,均为自然食物,为实验组患者提供符合同样原则的食谱安排,但以乳清蛋白粉替代自然食物中蛋白质含量的20%。两组患者均进行走跑类或者拳操类的中等强度有氧运动,每天30～40min,每周3～5次。结果①添加全乳清蛋白粉的患者体重明显下降,肝功能、血脂明显好转;B超显示脂肪肝程度明显减轻。食用普通食物的患者体重明显减轻,但HDL和LDL没有明显改善;肝功能有所好转,但是AST变化不显著;B超显示脂肪肝程度明显减轻。②与普通食物的对照组患者相比,普通食物+乳清蛋白患者虽然在肝功能恢复方面无明显不同,但是研究后TG、TC和LDL明显低于普通食物组。结论普通食物和及其添加乳清蛋白的两种干预方法都有利于NAFLD患者的脂肪肝病情改善,但是乳清蛋白+普通食物在降低血脂(血清甘油三酯、血清胆固醇、低密度脂蛋白胆固醇)方面效果更好。
Objective To observe the effect of whey protein powder on non-alcoholic fatty liver disease (NAFLD). Methods Sixty-one patients with confirmed NAFLD and lifestyle intervention were selected as study subjects, including 12 females and 49 males. Randomly divided into control group of 20 cases, 41 cases of experimental group for 12 weeks of treatment. The diet of patients in the control group meeting NAFLD nutrition guidelines was a natural diet that provided experimental groups with the same recipe but replaced whey protein powder with 20% of the protein content of natural foods. Two groups of patients were walking class or boxing class of moderate-intensity aerobic exercise, 30 ~ 40min a day, 3 to 5 times a week. Results ① The body weight of patients with total whey protein powder decreased significantly, and liver function and blood lipids improved obviously; B-ultrasound showed that the degree of fatty liver was significantly reduced. The body weight of patients with normal food significantly reduced, but no significant improvement in HDL and LDL; liver function improved, but the AST was not significantly changed; B-ultrasound showed that the degree of fatty liver was significantly reduced. ②Compared with the control group, the levels of TG, TC and LDL in normal food + whey protein were significantly lower than those in normal food group although they did not differ significantly in the recovery of liver function. CONCLUSIONS: Both normal diet and whey protein supplementation are beneficial for the improvement of fatty liver in patients with NAFLD. However, whey protein plus common food have significant effects on reducing blood lipid (serum triglyceride, serum cholesterol, low density lipoprotein cholesterol ) Is better.