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目的:探讨老年患者胃液中TNF-α,CA19-9和CEA联合检测对胃癌的诊断价值．方法:采用放射免疫技术测定42例胃癌和61例良性胃病老年患者胃液中TNF-α,CA19-9和CEA浓度．结果:胃癌组胃液中TNF-α,CA19-9和CEA的浓度显著高于良性胃病组(8．96±2．10 mg／L vs 4．92±1．24．5．66±1．25 mg／L;59．47±10．58 IU／L vs 36．89±11．23．38．73±9．23 IU／L; 31．68±5．58 mg／L vs 1’．55±3．82,19.42±5．19 mg／L,均P<0．001);胃癌组联合检测胃液中TNF-α,CA19-9和CEA,其敏感度和特异度分别97．4％,89．3％,均明显高于单项指标的敏感度和特异度．结论:联合检测胃液中TNF-α,CA19-9和CEA能有助于提高胃癌的诊断．
Objective: To investigate the diagnostic value of combined detection of TNF-α, CA19-9 and CEA in gastric juice in elderly patients. Methods: The concentrations of TNF-α, CA19-9 and CEA in gastric juice of 42 gastric cancer patients and 61 elderly patients with benign gastric diseases were determined by radioimmunoassay. Results: The concentrations of TNF-α, CA19-9 and CEA in gastric juice group were significantly higher than those in benign gastric disease group (8.96 ± 2.10 mg / L vs 4.92 ± 1.24.5.66 ± 1.25 mg / L; 59.47 ± 10.58 IU / L vs 36.89 ± 11.23.38.73 ± 9.23 IU / L; 31.68 ± 5.58 mg / L vs 1’.55 ± 3.82, 19.42 ± 5.19 mg / L, all P <0.001). The sensitivity and specificity of combined detection of TNF-α, CA19-9 and CEA in gastric cancer were 97.4%, 89 .3%, were significantly higher than the individual indicators of sensitivity and specificity. Conclusion: The combined detection of TNF-α, CA19-9 and CEA in gastric juice can help to improve the diagnosis of gastric cancer.