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目的:探讨血清透明质酸(HA),层粘连蛋白(LN),Ⅲ型前胶原(PCⅢ),Ⅳ型胶原(CⅣ)的测定在诊断肝纤维化中的意义。方法:采用放射免疫分析法分别对235例急、慢性肝炎,肝硬化,肝癌患者及46例健康人血清HA、LN、PCⅢ、Ⅳ-C检测,并进行了统计分析。结果:急慢性肝炎、肝硬化、肝癌的4项指标定量结果均高于对照组。结论:结合临床初步评价这四种1995年中华医学会《病毒性肝炎防治方案》推荐的肝纤维化指标在肝纤维化的诊断有较大意义。
Objective: To investigate the significance of determination of serum hyaluronic acid (HA), laminin (LN), type Ⅲ procollagen (PC Ⅲ), type Ⅳ collagen (C Ⅳ) in the diagnosis of liver fibrosis. Methods: The serum levels of HA, LN, PCⅢ, Ⅳ-C in 235 patients with acute and chronic hepatitis, cirrhosis, liver cancer and 46 healthy individuals were detected by radioimmunoassay and analyzed statistically. Results: Quantitative results of 4 indexes of acute and chronic hepatitis, cirrhosis and hepatocellular carcinoma were all higher than those of the control group. Conclusions: Combined with clinical preliminary evaluation, the four indicators of liver fibrosis recommended by the “Chinese Medical Association for Viral Hepatitis Prevention and Control” in 1995 are of great significance in the diagnosis of hepatic fibrosis.