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２，４－二异氰酸甲苯酯致敏豚鼠符合鼻变态反应，出现典型的鼻痒、喷嚏、流涕症状［积分值（６±０．９４）分］。实验表明：克鼻敏可减少鼻局部症状的积分值（Ｐ＜０．００１），并优于立复汀对照组。结果还显示克鼻敏对致敏豚鼠鼻粘膜肥大细胞释放组织胺介质的高含量有明显的抑制作用（Ｐ＜０．００５），同时亦降低血中含量，说明其作用是通过降低变应原对肥大细胞的刺激，减少组胺释放，从而有效地控制变应性鼻炎发生的。
2,4-Toluene sensitized guinea pigs were found to be allergic to nasal allergy and showed typical symptoms of nasal itching, sneezing, runny nose [score (6 ± 0.94) points]. Experiments show that: g nose can reduce the integral value of local nasal symptoms (P <0.001), and is better than the establishment of stereotyped control group. The results also showed that proboscis sensitive nasal mucosa of sensitized guinea pig nasal mucosa release of high levels of histamine medium significantly inhibited (P <0.005), but also reduce blood levels, indicating that its role is through the reduction of allergen Stimulation of mast cells reduces histamine release and thus effectively controls the occurrence of allergic rhinitis.