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目的探讨细胞S期激酶相关蛋白(Skp2)在子宫内膜样癌中的表达变化及其与患者临床病理特征的关系。方法选取山东省肥城矿业集团中心医院病理科2011年1月至2012年12月收集的83例子宫内膜样癌组织标本、同期收集的30例正常子宫内膜组织标本,分析Skp2蛋白表达与患者临床病理特征的关系。结果子宫内膜样癌组织中Skp2蛋白阳性表达41例,正常子宫内膜组织中Skp2蛋白阳性表达仅2例,子宫内膜样癌组织中的Skp2蛋白阳性表达率49.40%显著高于正常子宫内膜组织的6.67%(P<0.05);子宫内膜样癌组织中Skp2蛋白阳性表达与患者的临床分期、分化程度、发生淋巴结转移具有显著的相关关系(P<0.05)。结论 Skp2在子宫内膜样癌中表达水平显著升高,并且与患者的临床分期、分化程度、发生淋巴结转移具有密切关系。
Objective To investigate the expression of Skp2 in endometrioid carcinoma and its relationship with clinicopathological features. Methods Eighty-three specimens of endometrial carcinoma collected from January 2011 to December 2012 in Department of Pathology, Central Hospital of Feicheng Mining Group of Shandong Province were collected, and 30 cases of normal endometrial tissues collected in the same period were analyzed. The expression of Skp2 protein in patients with Clinicopathological characteristics of the relationship. Results The positive expression of Skp2 protein in endometrioid carcinoma was 41 cases, the expression of Skp2 protein in normal endometrium was only 2 cases, the positive expression rate of Skp2 protein in endometrial carcinoma was 49.40%, which was significantly higher than that in normal uterus (P <0.05). The positive expression of Skp2 protein in endometrioid carcinoma was significantly correlated with the clinical stage, differentiation and lymph node metastasis (P <0.05). Conclusion The expression of Skp2 in endometrioid carcinoma is significantly increased, and it is closely related to the clinical stage, differentiation degree and lymph node metastasis.