目的为了合成有效的手性配体,催化不对称杂Diels-Alder反应。方法联二萘酚(BINOL)通过两种不同氢化后得到5,5’,6,6’,7,7’,8,8’-八氢-1,1’-联二萘酚,在CH2Cl2溶液中,控制反应温度和反应时间,用单质溴取代,生成3,3’-二溴-5,5’,6,6’,7,7’,8,8’-八氢-1,1’-联二萘酚。结果产物产率可达到90%。结论此合成方法相对简单,却有很高的产率。 Aim To synthesize effective chiral ligands and catalyze the asymmetric hetero-Diels-Alder reaction. Methods Binaphthol (BINOL) obtained by two different hydrogenation of 5,5 ’, 6,6’, 7,7 ’, 8,8’-octahydro-1,1’-binaphthol, in CH2Cl2 Solution, the reaction temperature and reaction time are controlled and replaced with elemental bromine to produce 3,3’-dibromo-5,5 ’, 6,6’, 7,7 ’, 8,8’-octahydro- ’- binaphthol. The result is a product yield of up to 90%. Conclusion This synthetic method is relatively simple, but has a high yield.