本文报告优选法在药物大致半数致死量及最大耐受量测定中的应用,在大量药物过筛中取得多、快、好、省的结果。以芥子气抗毒药物为例,对所选择的剂量在毒性及过筛结果方面进行检验,并讨论了在药物初筛试验时,每个药物所用的动物数问题。 This article reports the application of the optimal method in the determination of the approximate lethal dose and the maximum tolerability of drugs, and obtains the results of more, faster, better and more results in the screening of a large number of drugs. In the case of mustard gas anti-virus drugs, the selected doses were tested for toxicity and screening results, and the number of animals used for each drug was discussed during drug screening tests.