针对超临界流体色谱分离强极性和离子型化合物时洗脱时间长及色谱峰拖尾状况 ,发展了离子对 超临界流体色谱 ,该项技术是超临界流体色谱的一个有效补充手段 ,扩展了其分析对象的范围。本文就离子对 超临界流体色谱的装置、原理及其在药物分析方面的应用进行综述 For supercritical fluid chromatography separation of highly polar and ionic compounds, long elution time and chromatographic peak tailing, the development of ion-pair supercritical fluid chromatography, the technology is an effective complement to supercritical fluid chromatography, expanding It analyzes the scope of the object. In this paper, the ion-pair supercritical fluid chromatography device, the principle and its application in drug analysis are reviewed