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消化系统癌是严重威胁人类健康的一类恶性肿瘤,其防治有赖于早期发现及选择合适的治疗方案。随着分子生物学的发展,肿瘤标志物在消化道癌检测诊断中的应用,使消化道癌的早期发现成为可能。本文简述了肿瘤标志物及其意义、主要类型;并对肿瘤标志物在消化系统癌高危人群的筛查及诊断,肿瘤分期、部位、大小、浸润深度,复发与转移的监测等进行了综述;同时对两种或多种肿瘤标志物联合检测,对提高消化道肿瘤的早期诊断率、增进疗效、判断预后和检出复发等作以展望。
Digestive system cancer is a kind of malignant tumor which is a serious threat to human health. Its prevention and treatment depend on early detection and selection of suitable treatment plan. With the development of molecular biology, the application of tumor markers in the diagnosis and detection of digestive tract cancer makes early detection of gastrointestinal cancer possible. This article describes the tumor markers and their significance, the main types; and screening of cancer markers in high-risk groups of digestive cancer screening and diagnosis, tumor staging, location, size, depth of invasion, recurrence and metastasis monitoring were reviewed ; Combined detection of two or more tumor markers at the same time, to improve the early diagnosis of gastrointestinal tumors, improve the efficacy, prognosis and detection of recurrence for the future.