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目的查明山东地区肾综合征出血热(HFRS)的临床和流行特征、疫源地血清型别以及病人血清型与宿主动物血清型的关系,探讨疫源地血清型别的演变。方法采用IFA法检测抗原与抗体,分型分别采用IFA、HI和RPHI等技术,同时作病毒分离。结果HFRS患者汉城型(SEO)占91.48%,汉坦型(HTN)占7.12%,未定型占1.31%,以SEO感染占优势。近年疫区的扩大与患者剧增主要由SEO病毒感染所致。HFRSV抗原型别和血清型均宿主种类相一致,即为家鼠HFRS抗原型别和血清型均为SEO,野鼠为HTN。并与疫区患者血清型相一致。两型患者发病高峰不同,临床特征基本相似,临床分型均有轻型和重型。分离毒株抗原型和毒力有差别,检出含有HTN病毒抗原成分的SEO病毒株。结论山东地区HFRS是SEO为主的混合型疫区,同时是否存在新的病毒感染者还需进一步研究。近年疫区的扩大与患者剧增主要由SEO病毒感染所致。
Objective To identify the clinical and epidemiological characteristics of hemorrhagic fever with renal syndrome (HFRS) in Shandong, the relationship between the serotypes of serogroups of patients and the serotypes of host animals, and the evolution of serotypes of the epidemic areas. Methods IFA, IFA, HI and RPHI were used to detect the antigen and antibody respectively, and the viruses were separated at the same time. Results The SEO of HFRS patients accounted for 91.48%, Hanning type (HTN) accounted for 7.12%, unstructured accounted for 1.31%, SEO predominance. In recent years, the expansion of the epidemic area and the surge of patients mainly caused by SEO virus infection. HFRSV antigen type and serotype are host species are consistent, that is, for home mouse HFRS antigen type and serotype are SEO, wild rat HTN. And consistent with the serotypes of infected patients. Two types of patients with different peak incidence, clinical features are similar, clinical types are light and heavy. The isolates have different antigenicity and virulence, and SEO virus strains containing HTN virus antigen components are detected. Conclusion HFRS in Shandong is a predominantly mixed-type epidemic area of SEO, and whether there is a new virus infection needs further study. In recent years, the expansion of the epidemic area and the surge of patients mainly caused by SEO virus infection.