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曾在一些哺乳类动物体内发现有卵细胞透明带特异性抗原,针对此抗原的抗体可以通过复盖透明带外的精子受体而在体内、外抑制受精。许多研究报告表明人血清中有抗透明带活性存在。因此有人认为针对透明带的自身抗体的存在可能与不孕有关。到目前为止所有的报导都仅仅分析了少数血清标本。本文作者利用免疫荧光和链霉蛋白酶诱发的透明带溶解抑制实验等方法研究分析了945例血清标本。其中正常男性198例、女性229例(年龄1～66岁);孕妇81例(孕20～40周);不孕症女性185例、男性145例(不明原因之不孕达2年以上),以及有正
Egg cell zona pellucida-specific antigen has been found in some mammals. Antibodies against this antigen can inhibit fertilization in vitro and in vivo by covering the sperm receptor outside the zona pellucida. Many studies have shown that there is anti-zona activity in human serum. Therefore, some people think that the presence of autoantibodies against zona pellucida may be related to infertility. All reports so far have analyzed only a few serum samples. The authors used immunofluorescence and pronase-induced inhibition of zona pellucida dissolution assay analysis of 945 serum samples. Among them, 198 were normal and 229 were women (aged 1 to 66). There were 81 pregnant women (20 to 40 weeks old), 185 infertile women and 145 male patients (2 years or older with unexplained infertility) And there is positive