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绝经后妇女为防止骨质丢失、治疗更年期症状,须用激素替代治疗。单独口服雌激素可使血清脂蛋白产生有利的影响,但可引起子宫内膜增生或腺癌。周期性加用孕激素对子宫内膜有保护作用。因此,目前皆采用雌一孕激素联合疗法。但据报道,19去甲基睾酮衍生物——醋炔诺酮(NETA)及18甲基炔诺酮能拮抗雌激素对血脂及脂蛋白的有利影响。本文目的是研究连续应用雌-孕激素治疗对脂代谢的影响。
Postmenopausal women to prevent bone loss, treatment of menopausal symptoms, hormone replacement therapy required. Oral administration of estrogen alone can have a beneficial effect on serum lipoproteins, but can cause endometrial hyperplasia or adenocarcinoma. Periodic plus progesterone on the endometrial protective effect. Therefore, the current are used estrogen and progesterone combination therapy. However, it is reported that demethylated testosterone derivatives, norethindrone acetate (NERVA) and norethisterone 18, antagonize the favorable effects of estrogen on blood lipids and lipoproteins. The purpose of this article is to study the effects of sequential estrogen-progestin therapy on lipid metabolism.