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目的 探讨氟、砷及氟砷联合作用对肝、脑、肾损害的机理。方法 用高氟、高砷、高氟高砷饲料分别饲养小鼠 12mo ,分别检测肝、脑、肾的LPO和GSH含量和SOD及GSH Px活性。结果 与对照组比较 ,氟组、砷组及氟砷联合组GSH含量均显著降低 ;各组SOD活力显著降低 ;除脑组织GSH PX降低不明显外 ,其余各组均显著降低。结论 氟、砷及氟砷联合作用均可使小鼠肝、脑、肾LPO增强 ,抗氧化能力降低 ,而且发现氟砷联合拮抗作用并不明显。
Objective To investigate the mechanism of liver, brain and kidney damage induced by the combination of fluoride, arsenic and fluoride and arsenic. Methods Mice were fed with high fluoride, high arsenic, high fluoride and high arsenic diet for 12 months. The contents of LPO and GSH, SOD and GSH Px in liver, brain and kidney were measured respectively. Results Compared with the control group, the contents of GSH in the fluoride group, the arsenic group and the fluoride-arsenic combination group were significantly decreased. The SOD activity in each group was significantly reduced, while the GSH PX in the brain tissue was not significantly reduced. Conclusion The combination of fluoride, arsenic and fluoride-arsenic can increase LPO, anti-oxidation ability of liver, brain and kidney of mice, and found that antagonism of fluoride and arsenic is not obvious.