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柴胡桂枝汤是柴胡、桂枝、芍药、生姜、甘草、人参、黄芩、半夏和大枣的混合物。先前的研究表明,柴胡桂枝汤对蜗牛神经元的放电活动有抑制作用,对音源性癫痫发作小鼠有抗癫痫作用。我们今于此报导柴胡桂枝汤及其组成单味药柴胡、桂枝、人参、生姜和甘草的局麻作用。材料和方法在本实验中所用的柴胡桂枝汤成分如下:柴胡5.0g、黄芩3.0g、半夏5.0g、芍药6.0g、桂枝2.0g、大枣4.0g、人参3.0g、甘草1.5g和生姜2.0g。生姜产自台湾,人参来自朝鲜,其余来自中国。实验用提取物按下法制备:将上述生药置于600ml水中,微沸30～40分钟,得到煎液约300ml。煎液经真空浓缩。将所得粉状提取物溶于蛙用任氏液中,浓度为1％和2％,pH调至7.0。
Chaihu Guizhi Tang is a mixture of Bupleurum, Guizhi, peony, ginger, licorice, ginseng, astragalus, pinellia, and jujube. Previous studies have shown that Chaihu Guizhi Decoction has an inhibitory effect on the activity of snail neurons and has antiepileptic effects on acoustically seizure mice. We report here on the local anesthetic effect of Chaihu Guizhi Decoction and its constituent single herbs Bupleurum, Guizhi, Ginseng, Ginger and Licorice. Materials and Methods The composition of Chai Hu Gui Zhi Tang used in this experiment was as follows: Bupleurum chinense 5.0 g, Radix Astragali 3.0 g, Pinellia radiata 5.0 g, peony 6.0 g, cassia twig 2.0 g, jujube 4.0 g, ginseng 3.0 g, and licorice 1.5 g. And ginger 2.0g. Ginger is produced in Taiwan, ginseng comes from North Korea, and the rest comes from China. Experimental extracts were prepared as follows: The above crude drug was placed in 600 ml of water and micro-boiled for 30-40 minutes to obtain about 300 ml of decoction. The decoction was concentrated in vacuo. The resulting powdery extract was dissolved in Rune’s frog solution at concentrations of 1% and 2% and the pH was adjusted to 7.0.