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下呼吸道中蛋白酶和抗蛋白酶间的平衡失调,据信在肺的急、慢性损害中起重要作用。成人呼吸窘迫综合征、肺气肿和弥漫性肺纤维化均与肺内蛋白分解酶的活性有关。肺结节病的细胞学机理和临床结局,与伴有肺间质病变的胶原性血管疾病(CVD)有着显著的差别,前者是以影响肺泡巨噬细胞和淋巴细胞的免疫细胞活性的增强为其特征,而累及肺间质的 CVD 则常以巨噬细胞数增高并伴有由性白细胞或淋巴细胞增多(或
The imbalance between protease and antiprotease in the lower respiratory tract is believed to play an important role in the acute and chronic lung injury. Adult respiratory distress syndrome, emphysema and diffuse pulmonary fibrosis are associated with the activity of intrapulmonary proteolytic enzymes. The cytological mechanism and clinical outcome of pulmonary sarcoidosis are significantly different from that of collagen-induced vascular disease (CVD) associated with interstitial lung disease. The former is based on the enhancement of immune cell activity that affects both alveolar macrophages and lymphocytes as Its characteristics, and involving lung interstitial CVD is often increased in the number of macrophages and accompanied by increased leukocytes or lymphocytes (or