癫痫发作可以对神经细胞产生损伤，早期发现并正确评估癫痫发作后脑细胞损伤的严重程度对临床诊疗有重要指导作用。近年来，人们已经在某些神经系统疾病中开始使用特异生物学标志物来评估疾病疗效及预测疾病预后。因此，寻找反映癫痫患者脑组织病变的生化特异性指标，并且监测血清和（或）脑脊液中这些指标的含量变化，对判断病情、评估预后以及临床干预意义重大。“,”Epilepsy is a common pediatric neurology emergency,which can often damage the neuronal cells.Early detection and correct evaluation of the severity of brain injury after seizures have important guid-ing role in the clinical diagnosis and treatment.In recent years,people have begun using some specific biolog-ical markers to evaluate treatment effect and prognosis in some diseases of the nervous system .Therefore,it is important for us to look for the specific biochemical indicators which can reflect the intracranial pathological tissue of epilepsy patients,and it is also meaningful to monitor these indicators in serum and/or cerebral spi-nal fluid for the condition judgment,prognostic evaluation and clinical intervention.