本文写成至校样的一年多时间,美登素全合成研究进展很快。Meyors组用已有环氧官能团的片段,按照合成(±)-N-甲基美赛宁的路线合成了(±)-美辛。Corey组用不饱和已糖作原料,毋需拆分直接制得(-)-N-甲基美赛宁。Fried组报导了通过醛醇缩合反应在C8和C9间闭环,同时形成六元环和十九元环的模型试验结果。后藤等发展出一种非环系统杂原子共轭加成的高度立体选择性反应,从D-甘露糖开始合成了包括C3-C11的光学活性中间体。白东鲁、周启廷等也已制得在C2-C3处开环的美登素直链前体。最近私人通讯获悉Corey等用R(+)-对-甲苯基苯 This article is written to proofs more than a year, the progress of Maytton synthesis research is fast. The Meyors group synthesized (±) - metsin using a fragment of an existing epoxy functional group following the route to the synthesis of (±) -N-methylmesacene. Corey group with unsaturated sugar has been used as raw material, without resolution directly (-) - N-methyl methanesulfon. The Fried group reported the results of a model test for the formation of six-membered and nineteen-membered rings by the aldol reaction between the C8 and C9 rings. Goto et al. Developed a highly stereoselective reaction of a non-ring system heteroatom-conjugate addition. Starting from D-mannose, an optically active intermediate including C3-C11 was synthesized. Bai Donglu, Zhou Qiting and others have also prepared maytansinoid linear precursors that are ring-opened at C2-C3. Recently Private Correspondence was informed that Corey et al. Used R (+) - p-tolylbenzene