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目的评价杜氟合剂预防剖宫产术中卡前列素氨丁三醇诱发的不良反应的效果。方法拟在腰硬联合麻醉下行择期子宫下段剖宫产术患者60例,随机分为对照组(C组)和杜氟合剂组(DF组)。于胎儿娩出后、使用卡前列素氨丁三醇前2min,DF组静注杜氟合剂半剂,C组静注等容量的生理盐水。记录卡前列素氨丁三醇给药后恶心、呕吐、胸闷、面色潮红和心血管不良事件的发生情况,记录卡前列素氨丁三醇给药前(T0)、给杜氟合剂后10min(T1)和手术结束时(T2)产妇的警觉与镇静评分(OAA/S评分)。结果 DF组卡前列素氨丁三醇不良反应的发生率低于C组(P<0.01)。T1、T2时DF组的OAA/S评分低于C组(P<0.01)。DF组T1、T2时OAA/S评分与T0时比较出现显著降低(P<0.01)。结论剖宫产术中,卡前列素氨丁三醇给药前静注杜氟合剂有助于预防其诱发的胃肠道和心血管不良反应的发生。
Objective To evaluate the efficacy of doxoflurane in preventing the adverse reactions induced by carboprost in cesarean section. Methods Sixty patients undergoing elective cesarean section under elective lumbar epidural anesthesia were randomly divided into control group (C group) and doxorubicin group (DF group). After the fetus was delivered, 2 minutes before the use of cardoprost trometamol, DF group was intravenously injected with half a dose of doxorubicin, and C group was injected with normal saline of equal capacity. The incidences of nausea, vomiting, chest tightness, flushing and cardiovascular adverse events were recorded after the administration of cardoprost trometamol. The cardioprotective activity was recorded before cardiotoxicillin administration (T0) T1) and end of surgery (T2) maternal alertness and sedation scores (OAA / S score). Results The incidence of adverse effects of carboprost tromethamine in DF group was lower than that in C group (P <0.01). The OAA / S scores of DF group were lower than those of C group at T1 and T2 (P <0.01). Compared with T0, OAA / S score of T1 and T2 in DF group decreased significantly (P <0.01). Conclusion In cesarean section, the administration of doxorubicin intravenously before administration of carboprost can help prevent gastrointestinal and cardiovascular adverse reactions.