药物的副作用常常妨碍各种心血管疾病的治疗,例如利用心得安、利多卡因或乙胺碘呋酮进行抗心律失常的治疗时,由于会产生与药物有关的心脏和全身的副作用而使治疗复杂化。应用控释植入剂就可以避免这类问题。本文中所要讨论的是在心血管系统内的病灶区,用这种局部的给药方法在用药部位产生局部的高浓度,而全身的药物浓度则较低,可以既达到疗效又避免了副作用。药物可被混合在一种控释系统中,在基质中作为分散物,或作为“贮存”(reservoir)的片心。广泛应用的非降解基质聚合物有乙烯乙酸乙烯酯、硅橡胶和聚亚胺酯。将生物降解骨架材料用于控释植入剂常常是有利的,已有人对聚 Side effects of drugs often prevent the treatment of a variety of cardiovascular diseases, such as anti-arrhythmic treatment with propranolol, lidocaine or amiodarone, resulting in drug-related cardiac and systemic side effects complication. The use of controlled release implants to avoid such problems. What we are discussing in this article is the focal area within the cardiovascular system. This local delivery method produces a localized high concentration of the drug at the site of administration, while the systemic drug concentration is lower, both in terms of efficacy and avoidance of side effects. The drug can be mixed in a controlled release system, dispersed in the matrix, or used as a “heart” reservoir. Widely used non-degradable matrix polymers are ethylene vinyl acetate, silicone rubber and polyurethane. It is often advantageous to use biodegradable scaffolds for controlled release implants, which have been found to be well established