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目的探讨有T2DM家族史且BMI正常的青少年空腹血浆中Ghrelin水平的变化及相关影响因素。方法 80名13～15岁BMI正常青少年,根据有无糖尿病家族史分为糖尿病家族史阳性组(FHD~+)和糖尿病家族史阴性组(FHD~-)。测量身高、体重及血压,检测FPG、血脂、空腹真胰岛素(FTI)及Ghrelin水平。结果 FHD~+组BMI、FPG、FTI和胰岛素抵抗指数(HOMA-IR)高于FHD~-组(P<0.05),空腹Ghrelin水平低于FHD~-组(P<0.01)。Ghrelin与FPG(r=-0.456,P<0.01),FTI(r=-0.183,P<0.05)和HOMA-IR(r=-0.237,P<0.01)呈负相关。以Ghrelin为因变量,行多元线性回归显示,FPG(β=-354.435,P<0.01)和FHD(β=-176.468,P<0.01)为独立危险因素。结论有T2DM家族史的BMI正常的青少年已存在空腹Ghrelin水平的降低,FPG的升高和糖尿病家族史可能是Ghrelin水平降低的相关因素。
Objective To investigate the changes of Ghrelin level in adolescents with T2DM family history and normal BMI and related factors. Methods Eighty BMI normal adolescents aged 13-15 years old were divided into FHD + group and FHD group according to the presence or absence of family history of diabetes. Height, weight and blood pressure were measured. FPG, blood lipids, fasting true insulin (FTI) and Ghrelin levels were measured. Results The BMI, FPG, FTI and HOMA-IR of FHD ~ + group were higher than those of FHD ~ - group (P <0.05), while the fasting Ghrelin level was lower than that of FHD group (P <0.01). Ghrelin was negatively correlated with FPG (r = -0.456, P <0.01), FTI (r = -0.183, P <0.05) and HOMA-IR (r = -0.237, P <0.01). Using Ghrelin as the dependent variable, multiple linear regression showed that FPG (β = -354.435, P <0.01) and FHD (β = -176.468, P <0.01) were independent risk factors. Conclusion There is a fasting Ghrelin level in adolescents with a family history of T2DM. Elevated FPG and family history of diabetes may be related to the decrease of Ghrelin level.