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目的:动态监测分析血栓前体蛋白(TpP)对心脏瓣膜置换术后抗凝治疗及检测的临床价值。方法收集2012年5月~2013年5月于本院开展心脏瓣膜置换术的40例患者为研究对象,将其随机均分为观察组和对照组,两组均于术前1 d,术中(开放主动脉30 min后),术后第2、3天检测各项指标,其中对照组仅检测凝血酶原时间(PT)、国际标准化比值(INR),观察组同时检测TpP、PT和INR,比较两组的INR和PT值,评价敏感性。结果两组术前1 d,术中,术后第2、3天PT及INR差异无统计学意义(P>0.05)。两组脑栓塞、轻度出血发生率差异无统计学意义(P>0.05)。心房颤动与窦性心律患者的INR比较,差异无统计学意义(P>0.05),TpP比较,差异有统计学意义(P0.05).The incidence of cerebral embolism and mild bleeding of two groups had no signifi-cant difference (P>0.05).The INR of patients with atrial fibrillation and sinus rhythm had no significant difference (P>0.05),but the TpP had significant difference (P<0.05). Conclusion The important indexes of TpP and INR do not have significant correlation,but their examination can effectively guide the anticoagulant treatment,especially those who with the TpP value too low,the bleeding threatening should be paid attention to.