以 GGl_4 连续饲喂大白鼠在早期可以引起严重的坏死性中毒性肝炎,随即出现肝细胞再生,至晚期可形成“结节性肝硬变”。以 GGl_4反复注射亦可造成明显的肝硬变。但给药的剂量、间隔与肘限与病变的可逆性以及能否形成肝硬变有密切关系。过去我们曾观察到在肝细胞坏死严重的时期,肝组织的呼吸酶、转氨酶、精氨酸酶和过氧化氢酶活力都有显著的降低,同时伴以后三种酶在血清内明显增高。 GGl_4 continuous feeding rats in the early stage can cause severe necrotizing toxic hepatitis, hepatocyte regeneration occurs immediately, to the late can form “nodular cirrhosis.” Repeated injection of GGl_4 can also cause significant cirrhosis. However, the dose, interval and elbow limits and the reversibility of the disease and whether the formation of cirrhosis are closely related. In the past we have observed that in severe liver necrosis period, liver tissue respiration enzyme, transaminase, arginase and catalase activity were significantly reduced, accompanied by the latter three enzymes was significantly increased in serum.